神经酰胺(ceramide,CE)是人体自身存在的一类复杂多样的脂质,不仅是维持细胞膜结构的重要组分,而且能够对细胞生长、分化、凋亡等多种生理活动进行调节,可作为第二信使转运凋亡信号,在细胞凋亡过程中具有决定性作用。综述神经酰胺的生成及代谢过程,概括其抗肿瘤及逆转多药耐药的作用机制,可帮助了解其作为药物载体或药物在肿瘤治疗领域的最新进展。 Ceramide (CE) is a kind of complex and diverse lipid that exists in human body itself. It not only regulates the cell membrane structure, but also regulates various physiological activities such as cell growth, differentiation and apoptosis, The second messenger transports the apoptotic signal, which plays a decisive role in the process of apoptosis. This review summarizes the formation and metabolism of ceramide and summarizes its mechanism of anti-tumor and reversal of multi-drug resistance, which can help to understand the latest advances in the field of tumor therapy as a drug carrier or drug.