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血管平滑肌细胞(VSMC)增殖的过程涉及到细胞周期的调控,S期激酶相关蛋白2(Skp2)能介导泛素化蛋白通过泛素蛋白酶降解途径进行降解,参与了细胞周期调控,与VSMC增殖密切相关。本文就Skp2与VSMC的增殖关系作一综述。
Proliferation of vascular smooth muscle cells (VSMCs) involves the regulation of the cell cycle. Skp2 can mediate the degradation of ubiquitinated proteins through ubiquitin protease degradation pathway, which is involved in cell cycle regulation and VSMC proliferation closely related. This article reviews the relationship between the proliferation of Skp2 and VSMC.