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目的①建立鸡甲胺磷中毒迟发性神经病模型。②通过周围神经电生理检测确定周围神经损伤情况并评价三磷酸胞苷二钠(CTP)对周围神经的保护作用。方法莱亨母鸡随机分为2组,甲胺磷经消化道染毒,从染毒后第2天开始A、B组分别每天给盐水和CTP1周,染毒后1、2、3、4、8周取鸡坐骨神经进行电生理检测。结果甲胺磷致迟发性神经病早期以轴索损害为主,继之出现脱髓鞘改变,但各组间比较差异无统计学意义。结论①利用甲胺磷染毒莱亨鸡可成功构建迟发性神经病模型。②电生理检测阳性率高,且早于临床体征的出现,是诊断迟发性神经病的客观指标之一。③本病有自愈倾向,远期预后较好。
Objective ① To establish a model of delayed neuropathy of methamidophos in chickens. ② Peripheral nerves electrophysiological detection to determine the situation of peripheral nerve injury and evaluate the protective effect of cytidine triphosphate disodium (CTP) on the peripheral nerve. Methods Lechine hen were randomly divided into two groups. Methamidophos was administered through the digestive tract. From the second day after exposure, the rats in groups A and B were given saline and CTP for 1 week each day. After exposure for 1, 2, 3, 4 , 8 weeks to chicken sciatic nerve for electrophysiological testing. Results Early methamidophos-induced delayed neuropathy was mainly axonal injury, followed by demyelination, but there was no significant difference between the groups. Conclusion ① The leiheng chickens with methamidophos can successfully construct the delayed neuropathy model. ② electrophysiological detection of high positive rate, and early appearance of clinical signs, is an objective indicator of the diagnosis of delayed neuropathy. ③ The disease has a tendency to self-healing, long-term prognosis is better.