论文部分内容阅读
目的 动态监测PICU非感染外科患儿体温(T)、WBC、CRP和IL-6,探讨这些指标对发生医院感染(院感)的预测价值.方法 选取2016年6月23日至2017年3月15日入住复旦大学附属儿科医院PICU且符合本文纳入、排除和剔除标准的外科急危重症患儿.根据是否发生院感分为院感组和非院感组;记录4个时点T、WBC、CRP和IL-6[P1为入住PICU后4 h内,P2~P4分别为P1后(48±1)h、(120±1)h和(192±1)h],分析其对院感的预测价值.绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC)、灵敏度和特异度等.结果 42例患儿进入本文分析,院感组11例,非院感组31例,两组在性别,入PICU时年龄、体重、T、WBC、CRP、IL-6,基础疾病分布和有创操作分布方面差异均无统计学意义(P>0.05),两组中心静脉置管情况差异有统计学意义(P=0.03).院感组与非院感组T、WBC、CRP和IL-6差异均有统计学意义(P0.05),but were statistical differences for central venous catheterization between the two groups(P=0.03), when patients were just admitted to PICU. The statistical differences of T, WBC, CRP and IL-6 were significant between nosocomial infection group and non-nosocomoal infection group(P0.05).The 4 indicators could be made up into 11 combinations,and the AUC ranged from 0.754 to 0.842, the sensitivity ranged from 72.7% to 90.9%, and the specificity ranged from 71.0% to 96.8%. Conclusion The combination of T, WBC and IL-6 can be taken as an indicator for monitoring nosocomial infection with relatively high sensitivity and specificity.