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目的:探讨大豆异黄酮对去卵巢大鼠空间学习记忆和海马内单胺类递质及单胺氧化酶的影响。方法:青年雌性SD大鼠去除双侧卵巢造模。随机分为5组,对照组、模型组、苯甲酸雌二醇组、大豆异黄酮低、高剂量组。观察各组去卵巢大鼠Morris水迷宫学习能力以及海马内单胺类神经递质和海马单胺氧化酶的含量。结果:①对照组、苯甲酸雌二醇组、大豆异黄酮(IS)低剂量组3 d定位航行学习能力明显高于模型组(P<0.05)。对照组、苯甲酸雌二醇组、大豆异黄酮低剂量组空间探索能力明显高于模型组(P<0.05)。②对照组和IS高剂量组海马NE含量明显高于模型组,有统计学差异(P<0.05);对照组、IS低剂量组和苯甲组海马DA和5-HT含量明显高于模型组,有统计学差异(P<0.05)。③对照组、苯甲组、IS低剂量组海马MAO含量明显低于模型组,有统计学差异(P<0.05)。结论:低剂量大豆异黄酮通过提高海马内NE、DA、5-HT含量,降低海马MAO含量,提高去卵巢大鼠空间学习记忆能力。
Objective: To investigate the effects of soy isoflavones on spatial learning and memory, monoamine neurotransmitters and monoamine oxidase in hippocampus in ovariectomized rats. Methods: Young female Sprague-Dawley rats were ovariectomized. Randomly divided into 5 groups, control group, model group, estradiol benzoate group, soy isoflavone low and high dose group. Morris water maze learning ability and monoamine neurotransmitters and monoamine oxidase in the hippocampus were observed in ovariectomized rats. Results: ① In the control group, estradiol benzoate group and soy isoflavone (IS) low-dose group were significantly higher than model group (P <0.05). The space exploration ability of the control group, the estradiol benzoate group and the soy isoflavone low dose group was significantly higher than that of the model group (P <0.05). (2) Compared with model group, the content of NE in hippocampus in control group and IS high dose group was significantly higher than that in model group (P <0.05); the content of DA and 5-HT in hippocampus of control group, , There was statistical difference (P <0.05). ③ The contents of MAO in the hippocampus of the control group, the benzene group and the IS low-dose group were significantly lower than those in the model group (P <0.05). Conclusion: Low-dose soy isoflavones can improve spatial learning and memory in ovariectomized rats by increasing NE, DA and 5-HT content in hippocampus, decreasing MAO content in hippocampus.