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目的探讨尖锐湿疣(CA)患者抑郁情绪障碍与细胞免疫功能的关系。方法采用自评抑郁量表(SDS)对60例CA患者进行情绪评定,并比较分析了抑郁者与无抑郁者的外周血单一核细胞(PBMC)产生白介素2(IL-2)的能力、天然杀伤(NK)细胞活性。结果CA患者的SDS评分明显高于对照组(P<0.01),抑郁障碍的发生率为43.33%。CA患者中治疗时间长者(>3个月)比治疗时间短者(≤3个月)抑郁均分显著增高(P<0.05)。具有抑郁情绪障碍者,PBMC产生IL-2的能力、NK细胞活性明显降低(P<0.05或P<0.01)。结论CA患者存在明显的抑郁情绪障碍问题,且抑郁者细胞免疫功能低下。
Objective To investigate the relationship between the depression disorder and cellular immune function in patients with condyloma acuminatum (CA). Methods Sixty patients with coronary heart disease (CA) were evaluated by SDS, and the ability of interleukin 2 (IL-2) production by peripheral blood mononuclear cells (PBMCs) from depression and non-depression was compared. Natural Killer (NK) cell activity. Results The SDS score of CA patients was significantly higher than that of the control group (P <0.01), and the incidence of depression was 43.33%. The depression scores of elderly patients (> 3 months) with shorter treatment time (≤3 months) in CA patients were significantly higher (P <0.05). People with depressive mood disorders, PBMC IL-2 production capacity, NK cell activity was significantly reduced (P <0.05 or P <0.01). Conclusion CA patients have obvious depression disorder, and depression in patients with cellular immune function.