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临床报道植物药筋骨草有降压作用。我们用该草药的半合成有效单体——木犀草素作了急性降压的动物试验,结果证明木犀草素对猫、狗均具明显而缓慢的急性降压作用。颈动脉窦加压反射、颈总动脉给药及第四脑室给药均显示出血压下降,这说明其降压与中枢有关。使用心得安可减弱木犀草素的降压效应,说明木犀草素的降压作用与激动β受体有关。实验还显示出木犀草素具有桔抗垂体后叶素的升压效应,说明该药有直接扩张血管作用。
Clinical reports of plant medicine Bugu grass has antihypertensive effect. We used the herbal semi-synthetic effective monomer - luteolin for acute antihypertensive animal tests, the results show that luteolin on cats and dogs have a significant but slow acute antihypertensive effect. Carotid sinus pressure reflex, common carotid artery administration and the fourth ventricle administration showed decreased blood pressure, indicating that its antihypertensive and central. Use experience Anker can reduce the hypotensive effect of luteolin, indicating that the antihypertensive effect of luteolin and agonist β receptor. The experiment also showed that luteolin has anti-pituitary hormone vasopressin effect, indicating that the drug has a direct dilation of blood vessels.