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目的研究高敏 C 反应蛋白(hs-CRP)与格雷夫斯病(GD)不同并发症的关系。方法比较 GD 者与对照组 hs-CRP 水平,GD 分为无并发症(1组)、甲亢危象(2组)、甲心病(3组)、浸润突眼(4组)、低钾周期瘫痪(5组)、白细胞低(6组)、肝损害(7组),比较各组年龄、病程、FT3、FT4、TRAh、hs-CRP 水平。结果各组间年龄、病程、FT3、FT4、TRAb 无差异。GD 患者 hs-CRP 明显高于对照组,其中1、3、4、7组 hs-CRP 与对照组相比差异显著,而5、6组与对照组相比无差异。2例甲亢危象 hs-CRP 为对照组90倍,为1组的31.1倍。hs-CRP浸润突眼4级以上与3级以下相比有明显差异:甲心病心衰Ⅱ度以上与无心衰者相比差异显著(P=0.006);但普通 GD 组与 GD 并发症各组间 hs-CRP 无明显差异(P 均>0.05)。结论 GD 者 hs-CRP 明显高于对照组,并发症越严重 hs-CRP 水平越高。
Objective To investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) and different Graves’ disease (GD) complications. Methods The levels of hs-CRP in GD and control groups were compared. GD was divided into no complications (group 1), hyperthyroidism (group 2), patients with congestive heart disease (group 3), infiltrating exophthalmos (group 4) (Group 5), low leukocyte (group 6), and liver damage (group 7). The age, course of disease, FT3, FT4, TRAh and hs-CRP were compared between groups. Results The age, course of disease, FT3, FT4, TRAb no difference among the groups. Hs-CRP in patients with GD was significantly higher than that in the control group, of which 1,3,4,7 hs-CRP significant difference compared with the control group, and 5,6 group and the control group no difference. 2 cases of hyperthyroidism crisis hs-CRP 90 times the control group, a group of 31.1 times. hs-CRP infiltrative exophthalmos more than 4 and 3 levels were significantly different compared to: heart failure in patients with heart failure Ⅱ and no significant difference compared with those without heart failure (P = 0.006); but the average GD and GD complications No significant difference in hs-CRP between groups (P> 0.05). Conclusion The hs-CRP in GD patients is obviously higher than that in control group. The more serious the complications are, the higher the hs-CRP level is.