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本文纵向观察了四氯化碳（ＣＣＩ－４）致鼠肝硬化模型血清甘胆酸（肝功能指标）、血浆胰高血糖素水平、平均动脉压（ＭＡＰ）、醛固酮以及钠排泄的变化。结果表明，随肝组织损伤，肝功能下降，血浆胰高血糖素水平逐渐升高，ＭＡＰ则于第７周显著降低，且胰高血糖素升高与ＭＡＰ下降呈显著负相关（ｒ＝－０．７５７７，Ｐ＜０．０１），第９周出现了尿钠潴留，上述结果表明，胰高血糖素升高可能是ＭＡＰ下降的部分原因，ＭＡＰ下降，可能是尿钠潴留的部分原因，而后者是腹水形成的基础。
In this paper, we observed the change of serum glycocholic acid (hepatic function index), plasma glucagon level, mean arterial pressure (MAP), aldosterone and sodium excretion in CCI-4 rat model of liver cirrhosis. The results showed that with the liver injury, liver function decreased, plasma glucagon levels gradually increased, while MAP decreased significantly at the seventh week, and there was a significant negative correlation between glucagon elevation and MAP depression (r = -0 .7577, P <0.01). Urine retention was found in the 9th week. The above results indicated that elevated glucagon may be partly responsible for the decrease of MAP. The decrease of MAP may be the reason of urinary sodium retention. Ascites is the basis for the formation.