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无味氯霉素在人体内的吸收与原料晶型有关。晶型A、非晶型及晶型B的疗效有显著的不同。本文对国产单方混悬液、复方混悬液及原料进行了人和兔的血浓度、红外光谱及显微观察等的研究,证实:无味氯霉素单方混悬液中的无味氯霉素主要为B型,吸收较好,血浓度较高,而复方混悬液和原料主要为A型,吸收较差。对国产A型和试制B型原料与法国A型和意大利B型原料的吸收也作了比较研究,证实:意大利B型和试制B型原料出现血浓度峰较早较高、剂型对吸收也有影响,以混悬液吸收最好,胶囊次之,片剂最差。但在用B型原料制成的片剂中加少量表面活性剂吐温-80,可增加吸收。
Odorless chloramphenicol absorption in the human body and the raw material crystal form. There is a significant difference in the efficacy of Form A, Form A and Form B. In this paper, domestic single-sided suspension, compound suspension and raw materials for human and rabbit blood concentration, infrared spectroscopy and microscopic observations, confirmed: Odorless chloramphenicol unimpaired suspension chloramphenicol mainly For the B type, better absorption, higher blood concentration, while the compound suspension and raw materials for the A-type, poor absorption. Comparative studies on the absorption of domestic type A and trial type B raw materials with French type A and Italian type B raw materials also confirmed that the peak of blood concentration peak appeared in Italian B and trial B materials and the dosage form also had an effect on absorption , To absorb the best suspension, followed by capsules, the worst tablet. However, with the B-type tablets made of raw materials plus a small amount of surfactant Tween-80, increased absorption.