目的探讨胃肠道间质瘤的临床表现、病理特征及诊疗措施。方法回顾性分析收治的21例胃肠道间质肿瘤的临床资料。结果 13例(61.9%)患者首发症状为消化道出血,5例(23.8%)为腹部胀痛不适;12例(57.1%)胃肠道间质瘤发生在胃。瘤细胞为梭形或上皮样,或两者混合存在。21例中20例CD117(+),9例CD34(+)。全组患者均行手术治疗,围手术期无患者死亡。术后1年存活率为90.1%,3年存活率为76.2%,5年存活率为61.9%。结论胃肠道间质瘤无特异的临床表现,术前明确诊断较困难。因瘤细胞有较独特的免疫组化表型,确诊依靠病理学及免疫组化,其中CD117阳性率大于95%。治疗主要依靠手术联合分子靶向药物的综合治疗。 Objective To investigate the clinical manifestations, pathological features and diagnosis and treatment of gastrointestinal stromal tumors. Methods The clinical data of 21 patients with gastrointestinal stromal tumors were retrospectively analyzed. Results Thirteen patients (61.9%) had initial gastrointestinal bleeding, 5 (23.8%) had abdominal discomfort, and 12 (57.1%) had gastrointestinal stromal tumors in the stomach. Tumor cells are fusiform or epithelial, or a combination of both. In 21 cases, 20 cases were CD117 (+) and 9 cases were CD34 (+). All patients underwent surgical treatment without perioperative death. 1 year survival rate was 90.1%, 3-year survival rate was 76.2%, 5-year survival rate was 61.9%. Conclusion Gastrointestinal stromal tumors have no specific clinical manifestations, and it is difficult to make clear diagnosis before operation. Due to tumor cells have a more unique immunohistochemical phenotype, confirmed by pathology and immunohistochemistry, CD117 positive rate of more than 95%. Treatment depends mainly on the combination of surgery and molecular targeted drugs.