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[目的]检测白介素-17A(IL-17A)、TGF-β在壹、贰、叁期尘肺病患者血清中的水平,探讨其在壹、贰、叁期尘肺病发生和发展过程中的作用,为尘肺病发病机制的研究提供参考。[方法]随机抽取尘肺病患者,按照尘肺壹、贰、叁期分为三组,每组50例;设置正常对照组50人,采集四组患者血清,使用ELISA法检测各组患者血清中IL-17A、TGF-β水平。[结果]壹、贰、叁期尘肺病患者血清IL-17A、TGF-β表达水平高于正常对照组,差异有统计学意义(P<0.01);壹期患者血清IL-17A水平高于贰、叁期患者,差异有统计学意义(P<0.01);而TGF-β血清表达水平随期别增高而升高,组间差异有统计学意义(P<0.01)。[结论]IL-17A、TGF-β在壹、贰、叁期尘肺病患者血清中存在高表达,早期检测TGF-β有助于了解疾病进展程度及严重程度。两者可能在尘肺早期及其发展过程中起到作用。
[Objective] To detect the levels of interleukin-17A (IL-17A) and TGF-β in sera of patients with pneumoconiosis of the first, second, and third stages, and to explore their roles in the pathogenesis and development of pneumoconiosis in the first, second and third trimester of pneumoconiosis. For the pathogenesis of pneumoconiosis provide a reference. [Method] Patients with pneumoconiosis were randomly selected and divided into three groups according to Pneumoconiosis One, Two and Three periods, with 50 cases in each group. Fifty normal controls were set up to collect sera from four groups. Serum IL -17A, TGF-β levels. [Results] The serum levels of IL-17A and TGF-β in patients with pneumoconiosis of the first, second and third stage were significantly higher than those of the control group (P <0.01). The level of IL-17A in the patients of the first stage was higher than that of the second (P <0.01). The serum level of TGF-β increased with the increase of the stage, the difference between the two groups was statistically significant (P <0.01). [Conclusion] IL-17A and TGF-β are highly expressed in sera of patients with pneumoconiosis of the first, second, and third stages. The early detection of TGF-β may help to understand the extent and severity of the disease progression. Both may play an early role in pneumoconiosis and its development.