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目的定量检测三碘甲状腺原氨酸(T_3)、游离T_3(FT_3)、肌钙蛋白I(cTnI)、肌红蛋白(Mb)以了解冠心病患者T_3、FT_3,是否有随病情加重而变化。方法A组:正常对照组50人,于早晨空腹取静脉血3ml送检;B组:冠心病患者无胸痛症状者107人,男68人,女39人,于早晨空腹取静脉血3ml送检;C组:冠心病患者有胸痛症状者58人,其中男39人,女19人,于胸痛后3h取静脉血3ml送检;A、B、C组全部采用全自动微粒子化学发光分析仪定量检测T_3、FT_3、cTnI、Mb。结果A组T_3浓度为2．08±0．62nmol/L、FT_3浓度为4．9±0．97nmol/L,cTnI浓度为0．27±0．18ug/L,Mb浓度为42±21ug/L;B组T_3浓度为1．68±0．43nmol/L、FT_3浓度为3．25±2．54nmol/L,cTnI浓度为0．31±0．19ug/L,Mb浓度为47±27ug/L,B有3例cTnI Mb显著增高,诊断为无痛性急性心肌梗死;C组T_3浓度为1．29±0．52nmol/L、FT_3浓度为2．93±1．12nmol/L、cTnI浓度为16．47±6．23ug/L,Mb浓度为496．84±253．12ug/L;C组与A组和B组比较有显著差异。结论对无痛性AMI患者何时检测cTnI Mb比较困难,目前尚无预测指标,T_3、FT_3的变化对无痛性AMI有提示作用。对有胸痛症状的冠心病患者检测cTnI Mb可早期诊断AMI,及时溶栓和治疗。
Objective To quantitatively detect the levels of T_3, FT_3, cTnI and Mb in coronary heart disease (CHD) patients to find out whether T_3 and FT_3 in patients with coronary heart disease are changed with the progression of the disease. Methods Group A: normal control group of 50 people in the morning fasting venous blood 3ml for inspection; B group: coronary heart disease patients without chest pain symptoms 107 people, 68 males and 39 females, in the morning fasting venous blood 3ml submission ; Group C: 58 patients with chest pain in CHD patients, including 39 males and 19 females, were given 3ml venous blood 3h after chest pain. A, B and C groups were all quantified by automatic particle chemiluminescence analyzer Detection T_3, FT_3, cTnI, Mb. Results The concentration of T_3 in group A was 2.08 ± 0.62nmol / L, the concentration of FT_3 was 4.9 ± 0.97nmol / L, the concentration of cTnI was 0.27 ± 0.18ug / L and the concentration of Mb was 42 ± 21ug / L ; The concentration of T_3 in group B was 1.68 ± 0.43nmol / L, the concentration of FT_3 was 3.25 ± 2.54nmol / L, the concentration of cTnI was 0.31 ± 0.19ug / L, the concentration of Mb was 47 ± 27ug / L , 3 cases of B cTnI Mb was significantly higher, the diagnosis of painless acute myocardial infarction; C group T_3 concentration of 1.29 ± 0.52nmol / L, FT_3 concentration of 2.93 ± 1.12nmol / L, cTnI concentration 16.47 ± 6.23ug / L, Mb concentration was 496.84 ± 253.12ug / L; There was a significant difference between group C and group A and group B. Conclusion It is difficult to detect cTnI Mb in patients with painless AMI. There are no predictive indexes at present. The changes of T_3 and FT_3 are indicative of painless AMI. Coronary heart disease patients with chest pain detection of cTnI Mb early diagnosis of AMI, timely thrombolysis and treatment.