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67例TORCH先天性感染的低出生体重儿,出生后至日龄7天经临床监护,实验室检查心、肺、脑、肝、肾功能表明,发热、贫血分别伴脏器损害和/或实验室检查异常占68.6％(24/35例)和55.50％(15/27例),提示先天性感染处于病毒血症期。TORCH感染心、脑均受损害分别为10％～33.3％和5.5％～10％;CMV、RV、HSV-Ⅱ均可导致先心病(8.8％,5/57例);CMV对肝脏损害和HSV-Ⅱ对骨骼致畸分别为16.7％(4/24例和3/18例)。提示潜伏性病毒CMV、HSV-Ⅱ对未发育成熟胎儿的脏器损害广泛;胎儿感染后第二次病毒血症持续时间与胎儿儿免疫系的早晚,病原体致病性特点及对脏器的损害程度,孕母感染类型及特异性IgG抗体对胎儿的保护作用,胎儿免疫系统发育的完善程度有关。
67 cases of congenital TORCH infection of low birth weight infants, after birth to 7 days of age by clinical monitoring, laboratory examination of heart, lung, brain, liver and kidney function, fever, anemia, respectively, associated with organ damage and / or experiment Abnormal laboratory examination accounted for 68.6% (24/35 cases) and 55.50% (15/27 cases), suggesting that the congenital infection is in the viremia phase. The damage of heart and brain in TORCH were 10% -33.3% and 5.5% -10%, respectively. CMV, RV and HSV-Ⅱ all caused congenital heart disease (8.8%, 5/57) -II on skeletal teratogenicity were 16.7% (4/24 cases and 3/18 cases) respectively. Prompt latent virus CMV, HSV-Ⅱ on immature fetus organ damage extensively; fetal infection after the second viremia and fetal immune system sooner or later, the pathogenicity of pathogens and organ damage Degree, the type of pregnant mother infection and specific IgG antibodies on the protection of the fetus, the development of fetal immune system, the degree of improvement.