发热、高胆红素血症是疾病常见的临床表现,多种病因均可出现发热伴高胆红素血症。最常见的病因仍然是感染性疾病,其次为肿瘤和结缔组织疾病。间接胆红素与直接胆红素的比例可初步判断增多胆红素的来源,影像学资料有助于发现胆道梗阻性疾病和肝内外占位性病变。该文介绍成人发热伴高胆红素血症的常见病因,旨在帮助临床医生形成准确的诊断思路。 Fever, hyperbilirubinemia is a common clinical manifestation of the disease, a variety of causes may be fever with hyperbilirubinemia. The most common cause is still infectious disease, followed by tumor and connective tissue disease. Indirect bilirubin and direct bilirubin ratio can be initially judged to increase the source of bilirubin, imaging data can help find biliary obstructive disease and intrahepatic and external lesions. This article describes the common causes of adult fever with hyperbilirubinemia, designed to help clinicians develop accurate diagnostic thinking.