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目的:探讨氨氯地平阿托伐他汀片联合舒心降脂片治疗高血压伴血脂异常的临床疗效。方法:将110例高血压伴血脂异常患者随机分为治疗组57例和对照组53例,均历2周的洗脱期,对照组给予舒心降脂片,4片/次,3次/d。治疗组加用氨氯地平阿托伐他汀片(多达一,5 mg/10 mg)1次/d,疗程24周。观察用药前后血脂、血压变化情况及心血管主要不良事件发生率。结果:治疗组血压控制的有效率明显高于对照组(P<0.05);两组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平较治疗前有显著改善,治疗组改善优于对照组(P<0.05);治疗组心血管主要不良事件发生率8.77%,对照组18.86%。结论:氨氯地平阿托伐他汀片联合舒心降脂片能有效控制高血压伴血脂异常患者血压,能显著改善血脂水平,是一种有效、安全的用药方案。
Objective: To investigate the clinical efficacy of amlodipine atorvastatin tablet combined with Shuxuening lipid-lowering tablet in the treatment of hypertension with dyslipidemia. Methods: A total of 110 hypertensive patients with dyslipidemia were randomly divided into treatment group (n = 57) and control group (n = 53), both of which were given elution period of 2 weeks. The control group was given Shuxuetaozhi tablet, 4 tablets / . Treatment group with amlodipine atorvastatin tablets (up to one, 5 mg / 10 mg) 1 / d, course of treatment for 24 weeks. Observed before and after treatment of blood lipids, blood pressure changes and the incidence of cardiovascular adverse events. Results: The effective rate of blood pressure control in the treatment group was significantly higher than that in the control group (P <0.05). The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein Cholesterol (HDL-C) was significantly improved compared with that before treatment, and the treatment group improved more than the control group (P <0.05). The incidence of major cardiovascular adverse events in the treatment group was 8.77% and that in the control group was 18.86%. Conclusion: Amlodipine atorvastatin tablets combined with Shuxuening lipid-lowering tablets can effectively control blood pressure in patients with hypertension and dyslipidemia, can significantly improve blood lipid levels, is an effective and safe drug program.