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目的探讨心力衰竭患者血浆B型利钠肽(BNP)浓度变化及其临床评价。方法采用化学发光法测定200例(100例住院心力衰竭患者及100例健康对照者)血浆BNP浓度。结果心力衰竭患者组血浆BNP水平显著高于健康对照组(P<0.001),且患者血浆BNP水平与心力衰竭严重程度呈正相关(r=0.95)。结论心力衰竭患者血浆BNP浓度显著升高,且与心力衰竭严重程度成正比,具有重要的临床意义。
Objective To investigate the changes of plasma B-type natriuretic peptide (BNP) in patients with heart failure and its clinical evaluation. Methods Chemiluminescence was used to determine plasma BNP levels in 200 patients (100 inpatients with heart failure and 100 healthy controls). Results Plasma BNP levels in patients with heart failure were significantly higher than those in healthy controls (P <0.001). Plasma BNP levels were positively correlated with the severity of heart failure (r = 0.95). Conclusion The plasma BNP concentration in patients with heart failure is significantly increased, and is proportional to the severity of heart failure, which has important clinical significance.