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目的：探讨首发精神分裂症患者血清心肌酶活性测定的临床价值。方法对观察组56例首发精神分裂症患者在入院时及治疗4周后分别采血检测血清心肌酶活性，包括肌酸激酶(CK)、肌酸激酶同功酶(CK-MB)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)及α-羟丁酸脱氢酶(α-HBDH)，并与对照组38例的心肌酶活性进行比较分析。结果观察组治疗前的血清心肌酶活性明显高于对照组(P <0.01)，治疗后血清心肌酶活性较治疗前明显降低(P 0.05)。结论首发精神分裂症患者血清心肌酶活性测定对判断患者病情及评定疗效有一定的临床价值。“,”Objective To explore the clinical value of serum cardiac enzymes activities detected in first-episode patients with schizophrenia. Methods The serum cardiac enzymes activities(including CK, CK-MB, AST, LDH andα-HBDH) of 56 first-episode patients with schizophrenia(observation group) were measured before treatment and after treatment of 4 weeks, and compared with that of control group. Results The cardiac enzymes activities of observation group before treatment were significantly higher than that of the control(P <0.01). Compared with before treatment, the serum cardiac enzymes activities of observation group decreased obviously after treatment(P 0.05). Conclusion Detection of serum cardiac enzymes activities in first-episode patients with schizophrenia have some clinical value for assessing the severity and therapeutic effect.