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一般认为,肾与内分泌尤其与垂体肾上腺系统关系密切,临床肾阳虚证有下丘脑——垂体——肾上腺轴功能紊乱。在实验方面,大剂量皮质素可制造动物阳虚证,用助阳药进行防治确能抗衡其致病作用。鉴于牙周病病因与祖国医学肾虚学说以及现代医学中牙周病内因的肾上腺皮质功能障碍有密切关系,为此,我们采用大剂量醋酸氢化可的松制造动物阳虚证,同时观察牙周组织学变化,以及合用助阳药的影响,为探索牙周病中西医学理论及中药防治提供根据。
It is generally believed that kidney and endocrine are particularly closely related to the pituitary adrenal system, and the clinical kidney-yang deficiency has hypothalamic-pituitary-adrenal axis dysfunction. In terms of experiments, large doses of corticosteroids can produce animal-deficiency syndromes, and prevention and treatment with adjuvant drugs can really counteract their pathogenic effects. Given that the etiology of periodontal disease is closely related to the doctrine of kidney deficiency in the motherland medicine and adrenocortical dysfunction in the internal cause of periodontal disease in modern medicine, we used large doses of hydrocortisone acetate to make animal deficiencies and observe periodontal tissue. The changes in learning and the effects of the combined use of positive-disease drugs provide a basis for exploring the theory of traditional Chinese medicine and prevention and treatment of periodontal diseases.