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目的观察多巴酚丁胺与酚妥拉明联用治疗煤工尘肺并慢性肺心病心力衰竭的疗效。方法将57例患者随机分成多巴酚丁胺--酚妥拉明组(观察组)及对照组。对照组采用常规治疗,治疗组在常规治疗的基础上,加用多巴酚丁胺与酚妥拉明,观察患者紫绀、肺部罗音、肝大、水肿及心功能情况等。结果治疗-疗程,观察组29例中显效21例.显效率72.4%,对照组28例中显效11例,显效率39.2%,两组比较有非常显著差异性(P<0.01),两组总有效率分别为93.1%和71.4%,有显著差异性(P<0.05)。结论煤工尘肺易并发慢性肺心病,且治疗较复杂,在常规治疗基础上,加用多巴酚丁胺与酚妥拉明能提高肺心病心力衰竭的疗效.
Objective To observe the efficacy of dobutamine combined with phentolamine in treating coal worker’s pneumoconiosis and chronic cor pulmonale heart failure. Methods 57 patients were randomly divided into dobutamine-phentolamine group (observation group) and control group. The control group was treated with conventional therapy. The treatment group was given dobutamine and phentolamine on the basis of routine treatment. The patients’ cyanosis, pulmonary rales, hepatomegaly, edema and cardiac function were observed. Results In the treatment-course of treatment, the effective rate was 72.4% in 29 cases in observation group and 11 cases in effective rate in control group, the effective rate was 39.2%. There was significant difference between the two groups (P <0.01) The effective rates were 93.1% and 71.4%, respectively, with significant differences (P <0.05). Conclusion Coal workers’ pneumoconiosis is complicated by chronic pulmonary heart disease, and the treatment is complicated. On the basis of routine treatment, the combination of dobutamine and phentolamine can improve the therapeutic effect of heart failure of pulmonary heart disease.