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目的探讨托吡酯对癫疒间患儿部分内分泌功能的影响。方法于2003年6月~2004年6月对山东省立医院儿科符合癫疒间诊断的36例患儿分别于治疗前、治疗3个月、治疗6个月测量血中部分内分泌激素,并对其进行比较。结果血三碘甲状腺氨酸(T3)在治疗3个月时较治疗前明显增高(P<0.05),6个月时增高不明显;而胰岛素、皮质醇、C-肽在治疗3个月、6个月时则明显降低(P<0.05),但在治疗3、6个月之间T3、胰岛素、皮质醇、C-肽并无明显变化;T4、TSH、生长激素在治疗过程中无明显变化;体重指数在治疗3个月时明显下降,6个月时又有所回升。结论托吡酯对生长激素无明显影响,不影响儿童的生长发育。
Objective To investigate the effect of topiramate on the partial endocrine function in children with epilepsy. Methods From June 2003 to June 2004, 36 children diagnosed with epilepsy in pediatric department of Shandong Provincial Hospital were measured before treatment, 3 months after treatment and 6 months after treatment, respectively, and some of the blood endocrine hormones were measured. It is compared. Results Blood triiodothyronine (T3) was significantly higher at 3 months than before treatment (P <0.05), but not significantly increased at 6 months. Insulin, cortisol and C-peptide were not significantly increased at 3 months, (P <0.05) at 6 months, but there was no significant change of T3, insulin, Cortisol and C-peptide in 3 and 6 months of treatment; T4, TSH and growth hormone had no significant difference in the course of treatment Changes; body mass index in the treatment of 3 months decreased significantly, 6 months and then picked up again. Conclusion Topiramate had no significant effect on growth hormone and did not affect children’s growth and development.