TAT是一种应用最早且现今最为常用的细胞穿膜肽,已经成功与多种纳米载体如脂质体、胶束、纳米粒等连结形成可内化进入细胞内的载药体系。文章主要对TAT介导的几种纳米载药体系的穿透机制、体内外抗肿瘤活性及靶向病变部位能力等方面的研究进行综述,同时对微环境pH敏感的TAT靶向药物载体的研究进展作了简单介绍。 TAT, the earliest and most commonly used cell penetrating peptide, has been successfully linked to various nanocarriers such as liposomes, micelles and nanoparticles to form drug-loaded systems that can be internalized into cells. This review focuses on the mechanisms of TAT-mediated penetration mechanism of several drug-loaded nanocarriers, antitumor activities in vitro and in vivo, and the ability to target lesion sites. At the same time, the study of pH-sensitive TAT-targeted drug carriers in microenvironment Made a brief introduction of progress.