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β-肾上腺素能受体阻滞剂治疗甲状腺机能亢进(简称甲亢)的确切机理尚不清楚。心得安治疗甲亢可使血清总三碘甲腺原氨酸(T_3)很快下降,这可能是因其在外周组织中影响甲状腺素(T_4)转化为 T_3及反 T_3。T_3的下降与氧耗量减少和体重增加有关。1例单独用心得安治疗9个月的 T_3甲亢患者,其临床和生化检查均示甲状腺功能正常。这进一步提示心得安除了有对β-肾上腺素能受体的阻滞作用外还有别的作用。但心得安对血循环中甲状腺激素作用持续时间的长短有争议,因此作者对8例 T_3甲亢患者(年龄46～66岁)进行研究。患者每日口服心得安
The exact mechanism of β-adrenergic receptor blocker for the treatment of hyperthyroidism (Hyperthyroidism) is unclear. Treatment of hyperthyroidism can make the serum total triiodothyronine (T_3) decreased rapidly, which may be due to its role in the peripheral tissue of thyroid hormone (T_4) into T_3 and anti-T_3. The decrease of T_3 is related to the decrease of oxygen consumption and weight gain. 1 case of propranolol alone for 9 months of T_3 hyperthyroidism patients, the clinical and biochemical tests showed normal thyroid function. This further suggests that there is an additional role aside from blocking the beta-adrenergic receptor. However, there is controversy over the duration of thyroid hormone effects in the blood circulation, so the authors studied 8 patients with T_3 hyperthyroidism (ages 46 to 66 years). Patients daily oral safety