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评价头孢布烯对临床分离的８３６株致病菌的体外抗菌作用。方法：头孢布烯与头孢克肟、头孢他啶、头孢噻肟、头孢呋辛、头孢克罗、头孢拉啶、环丙沙星进行比较。结果：头孢布烯对大多数革兰阴性菌具有很强的抗菌活性，如对大肠杆菌、肺炎克雷白杆菌、奇异变形杆菌、普通变形杆菌、沙门菌属、志贺菌属、粘质沙雷菌、阴沟肠杆菌的ＭＩＣ９０值均≤１ｍｇ·Ｌ－１，优于所测定的其他口服头孢菌素，与头孢他啶、头孢噻肟相似。头孢布烯对淋病奈瑟菌、流感嗜血杆菌也有很强的抗菌活性，但对某些肠杆菌科杆菌如弗劳地枸橼酸杆菌对本品与头孢他定相似不太敏感，ＭＩＣ９０值为８ｍｇ· Ｌ－１，乙酸钙不动杆菌对本品耐药， ＭＩＣ９０值为３２ ｍｇ·Ｌ－１。头孢布烯对革兰阳性菌除化脓性链球菌外作用均较弱。对肺炎链球菌的ＭＩＣ５０与ＭＩＣ９０值分别为２与４ｍｇ·Ｌ－１，不及其他所测定的三代头孢菌素。金黄色葡萄球菌、粪肠球菌、脆弱拟杆菌对头孢布烯耐药。从产酶大肠杆菌及肺炎克雷白菌的体外抗菌作用的结果表明，头孢布烯对产酶菌株具有较强的抗菌活性，ＭＩＣ９０值低于其他所测定的三代头孢菌素。结论：说明本品具有较强的β－内酰胺酶稳定性。细菌接种量、ｐＨ值的变化、人血清的含量对头孢市烯
To evaluate the in vitro antibacterial activity of ceftibuten against 836 pathogens isolated clinically. Methods: Ceftibuten was compared with cefixime, ceftazidime, cefotaxime, cefuroxime, cefaclor, cefradine and ciprofloxacin. Results: Ceftibuten has strong antibacterial activity against most Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Salmonella, Shigella, Leprosy, Enterobacter cloacae MIC90 values are ≤ 1mg · L-1, better than the other oral cephalosporins measured, and ceftazidime, cefotaxime similar. Ceftibuten on Neisseria gonorrhoeae, Haemophilus influenzae also has a strong antibacterial activity, but for some Enterobacteriaceae such as Freund Citrobacter on the goods and ceftazidime similar to the less sensitive, MIC90 value 8mg · L-1, Acinetobacter calcoaceticus resistance to this product, MIC90 value of 32 mg · L-1. Ceftibuten Gram-positive bacteria in addition to Streptococcus pyogenes outside the weaker. The MIC50 and MIC90 of Streptococcus pneumoniae were 2 and 4 mg · L-1, respectively, less than those of the third generation cephalosporins tested. Staphylococcus aureus, Enterococcus faecalis, Bacteroides fragilis ceftibuten resistant. The results of in vitro antibacterial activity of Escherichia coli and Klebsiella pneumoniae showed that ceftibuten has strong antibacterial activity against the enzyme-producing strains, and the MIC90 value is lower than that of other third-generation cephalosporins. Conclusion: This product shows strong β-lactamase stability. Bacterial inoculum size, pH value changes, the content of human serum against cefoperazone