妊娠期高血压疾病的病因极其复杂,其中关于血管内皮细胞损伤的原因就有很多。目前研究较多的是氧化应激学说,妊娠期高血压疾病氧化和抗氧化失衡,存在氧化应激。氧化应激产生大量活性氧、导致中性粒细胞炎性浸润以及释放多种蛋白酶,这些物质与膜和DNA结合产生脂质过氧化反应而致血管内皮损伤。 The cause of hypertensive disorders during pregnancy is extremely complex, there are many reasons for the damage of vascular endothelial cells. The current study is more oxidative stress theory, hypertensive disorders of pregnancy oxidation and antioxidant imbalance, the existence of oxidative stress. Oxidative stress produces large amounts of reactive oxygen species, leading to inflammatory infiltration of neutrophils and the release of multiple proteases, which bind to membrane and DNA to produce lipid peroxidation resulting in vascular endothelial damage.