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目的探讨新生儿败血症时外周血CD4+CD25+CD127low/-调节性T细胞(Treg细胞)的水平及其意义。方法用流式细胞仪检测26名正常足月新生儿(正常足月儿组)、14例单纯早产儿(单纯早产儿组)及21例新生儿败血症患儿(败血症组)外周血中CD4+CD25+CD127low/-Treg细胞的水平。结果正常足月儿组与单纯早产儿组差异无统计学意义(P>0.05);败血症组与正常足月儿组、单纯早产儿组比较均显著升高(均P<0.01)。结论外周血中Treg细胞的相对增加可能在新生儿败血症发生后淋巴细胞应答无能及免疫抑制中发挥作用。
Objective To investigate the levels and significance of CD4 + CD25 + CD127low / - regulatory T cells (Tregs) in peripheral blood in neonates with sepsis. Methods Flow cytometry was used to detect the levels of CD4 + in peripheral blood of 26 normal term neonates (normal full-term infants), 14 infants with premature infants (simple premature infants) and 21 infants with sepsis (sepsis) CD25 + CD127low / -Treg cells. Results There was no significant difference between normal full-term infants and premature infants (P> 0.05). The sepsis group was significantly higher than that of normal full-term infants and premature infants (all P <0.01). Conclusion The relative increase of Treg cells in peripheral blood may play a role in the impotence and immunosuppression of lymphocyte response after neonatal sepsis.