小儿严重感染时往往发生感染性休克(以下简称感休)。由于发病急,症状凶,变化快,死亡亦快。二十年来,我们在探索其发病机理的基础上,创用阿托品疗法以来,病死率显著降低。中毒性菌痢和暴发性流脑是引起小儿感休的主要疾病。前者的病死率从过去30～40%降低到1.0%,后者的病死率从过去的70%降低到9.5%.现将小儿感休有关问题讨 Severe infection in children often occurs septic shock (hereinafter referred to as flu). Due to acute onset, symptoms, rapid change, death is also fast. For two decades, we have significantly reduced the mortality rate after atropine therapy was developed on the basis of exploring its pathogenesis. Toxic bacillary dysentery and fulminant meningitis are the main causes of pediatric flu. The former case fatality rate from the past 30 to 40% to 1.0%, the latter case fatality rate from the previous 70% to 9.5%.