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目的探讨慢性乙型肝炎病毒(HBV)复制水平与丙氨酸氨基转移酶(ALT)之间的关系。方法对180例慢性乙型肝炎患者血清HBV DNA含量采用荧光标记(AmpliSensor)定量PCR方法检测,并比较HBV DNA含量与ALT的关系。结果慢性乙型肝炎轻度、中度患者HBV DNA含量(105.58±1.92,106.27±2.05)与慢性乙型肝炎重度患者HBV DNA含量(105.73±1.90)相比较差异无统计学意义(P>0.05),且不同HBV DNA水平患者的ALT差异无统计学意义(P>0.05)。结论随着肝损害程度的加重,慢性乙型肝炎患者血清HBV DNA基因含量未发生显著变化,同时血清HBV DNA含量与ALT水平无明显关系。
Objective To investigate the relationship between chronic hepatitis B virus (HBV) replication and alanine aminotransferase (ALT). Methods Serum HBV DNA levels in 180 patients with chronic hepatitis B were detected by AmpliSensor quantitative PCR, and the relationship between HBV DNA levels and ALT was compared. Results There was no significant difference in HBV DNA levels between mild and moderate CHB patients (105.58 ± 1.92 and 106.27 ± 2.05) and HBV DNA levels (105.73 ± 1.90) in patients with severe chronic hepatitis B (P> 0.05) , And there was no significant difference in ALT among patients with different HBV DNA levels (P> 0.05). Conclusions With the aggravation of liver damage, there is no significant change in the serum HBV DNA content in patients with chronic hepatitis B, meanwhile serum HBV DNA content has no significant relationship with ALT level.