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目的 探讨甲状腺髓样癌 (MTC)的病理学特点 ,诊断和治疗选择。方法 对 1982～ 2 0 0 1年经治的 32例MTC的临床和病理资料进行分析总结。结果 32例均予手术切除原发灶或加行颈淋巴结清扫术。均经病理证实 ,淋巴结转移率为 6 5 4%。术后 5年、10年生存率分别为 77 8%,6 2 5 %。结论 MTC具有多分化肿瘤的特点 ,可产生多种神经内分泌物质 ,少数病人可出现类癌综合征或顽固性腹泻。MTC的治疗以根治性切除为原则 ,而且要比其他类型的甲状腺癌更为积极 ,决不可任意缩小手术范围。
Objective To investigate the pathological features, diagnosis and treatment options of medullary thyroid carcinoma (MTC). Methods The clinical and pathological data of 32 MTC treated from 1982 to 2001 were analyzed and summarized. Results All the 32 cases were operated on primary resection or neck dissection. Pathologically confirmed, lymph node metastasis rate was 65.4%. After 5 years, the 10-year survival rates were 77 8% and 62 5% respectively. Conclusion MTC has the characteristics of multi-differentiated tumors, can produce a variety of neuroendocrine substances, a small number of patients may show carcinoid syndrome or intractable diarrhea. MTC treatment based on the principle of radical resection, but also more aggressive than other types of thyroid cancer, surgery must not be any way to narrow the scope.