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目的 :探讨P16基因纯合性缺失与非何杰金氏淋巴瘤 (NHL)的关系及其临床意义。方法 :采用半定量多重PCR检测了 5 1例非何杰金氏淋巴瘤病人P16基因纯合性缺失情况。结果 :发现 9例病人出现P16基因纯合性缺失 ,缺失率为 17.6 % ,且低度恶性组与高度恶性组有显著性差异 (P <0 .0 5 )。结论 :P16基因纯合性缺失主要发生于恶性程度较高的NHL中 ,可作为判断NHL恶性程度高低和决定NHL治疗策略的一个参考指标
Objective: To investigate the relationship between P16 gene homozygous deletion and non-Hodgkin’s lymphoma (NHL) and its clinical significance. Methods: The homozygous deletion of P16 gene in 51 non-Hodgkin’s lymphoma patients was detected by semi-quantitative PCR. Results: The homozygous deletion of P16 gene was found in 9 patients, the deletion rate was 17.6%. There was a significant difference between the low-grade group and the high-grade group (P <0.05). Conclusion: The homozygous deletion of P16 gene mainly occurs in NHL with high malignancy, which can be used as a reference index to determine the malignant degree of NHL and determine the treatment strategy of NHL