重度妊毒症为血管痉挛性疾病,以全身动脉压升高及循环血容量减少为特征。目前引起重度妊毒症的病因尚未明确,但近年来已了解该病能导致血液动力学的改变和心血管系统失调。但对这些变化是否为生理性的代偿功能还是必须纠正的严重病理——所谓慢性休克状态,还存在着不同的争论。一、正常妊娠血液动力学的变化在非孕期的正常情况下,有多种生理因素控制血压,其中最主要的因素为心逼出量及代表全身总阻力的全身小动脉的管径,依靠它们来维持有效循环量及各脏器的灌注压,见图1。从血液动力学的观点来讲,正常妊娠的特点是种植一个非常大的具有高流速及低阻力的血管网。在妊娠后期,子宫动脉直径增 Severe toxin is a vasospastic disease characterized by increased systemic arterial pressure and decreased circulating blood volume. The etiology of the current major gravidity is unclear, but it has been known in recent years that the disease can lead to hemodynamic changes and cardiovascular disorders. However, there are still different arguments about whether these changes are physiological compensatory functions or serious pathologies that must be corrected - the so-called state of chronic shock. First, the normal pregnancy hemodynamic changes in non-pregnancy under normal circumstances, there are many physiological factors control blood pressure, the most important factor is the cardiac output and the total body resistance of the systemic arterioles diameter, depending on them To maintain an effective circulation and perfusion pressure of various organs, shown in Figure 1. From a hemodynamic point of view, normal pregnancy is characterized by a very large vascular network with high flow rates and low resistance. In late pregnancy, uterine artery diameter increased