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目的研究间变性大细胞淋巴瘤(ALCL)中间变性淋巴瘤激酶(ALK)蛋白及survivin蛋白的表达特点及其临床意义。方法应用免疫组织化学LSAB法检测ALK蛋白及survivin蛋白的表达。结果ALK蛋白在81例ALCL中有51例(63%)阳性,30例(37%)阴性。ALK阳性患者预后优于阴性患者(P<0·05)。survivin蛋白在77例ALCL中均有不同程度的表达,其中高表达33例(42·9%),低表达44例(57·1%)。survivin的表达与ALK蛋白表达无关(P>0·05)。预后:Survivin高表达患者较低表达者差(P<0·05)。在ALK蛋白阳性病例中,survivin高表达患者较低表达者差(P<0·05);ALK阴性病例中,survivin的表达状况与预后无关(P>0·05)。Cox比例风险回归分析表明ALK的表达、体质性症状及survivin的不同表达状况对存活的影响有统计学意义(P<0·05),其中ALK的表达对生存的影响最大,survivin表达的影响最小。结论survivin蛋白在ALCL中的表达与ALK蛋白的表达不相关,是一个独立的指标,可有助于判断ALK阳性ALCL病例的预后。
Objective To investigate the expression of ALK protein and survivin protein in anaplastic large cell lymphoma (ALCL) and its clinical significance. Methods The expressions of ALK protein and survivin protein were detected by immunohistochemistry LSAB method. Results The ALK protein was positive in 51 cases (63%) of 81 cases of ALCL and negative in 30 cases (37%). The prognosis of ALK-positive patients was better than that of negative patients (P <0.05). Survivin protein was expressed in 77 cases of ALCL to varying degrees, of which 33 (42.9%) were highly expressed and 44 (57.1%) were low expressed. Survivin expression was not related to ALK protein expression (P> 0.05). Prognosis: Patients with high expression of Survivin had lower expression (P <0.05). In the ALK protein positive cases, the expression of survivin in patients with high expression was lower than that in patients with low expression (P <0.05). The expression of survivin in ALK negative cases had no correlation with prognosis (P> 0.05). Cox proportional hazards regression analysis showed that ALK expression, constitutional symptoms and different expression of survivin have a statistically significant effect on survival (P <0.05), of which ALK expression has the greatest impact on survival and survivin expression minimal impact . Conclusion The expression of survivin protein in ALCL is not correlated with the expression of ALK protein and is an independent indicator that may be helpful in judging the prognosis of ALK positive ALCL cases.