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目的探讨不同剂型的双唑泰制剂治疗细菌性阴道病的实际疗效并比较其疗效差异。方法回顾性分析2013年1月-2016年3月辽宁省妇婴医院妇科收治的细菌性阴道病(Bacterial vaginosis,BV)患者资料,根据使用药物不同将其分为双唑泰泡腾片组、双唑泰栓剂组、双唑泰软膏组和甲硝唑片口服对照组,治疗一个疗程后比较各组患者的临床疗效及复发率等指标。结果泡腾片组、栓剂组、乳膏组和对照组有效率分别为85.5%、80.0%、94.0%、67.5%,双唑泰泡腾片组、栓剂组、乳膏组3组有效率均优于对照组,差异均具有统计学意义(P<0.05);泡腾片组与栓剂组疗效相当,差异无统计学意义(P>0.05);软膏组疗效最佳,优于泡腾片组和栓剂组,差异具有统计学意义(P<0.05);泡腾片组、栓剂组、软膏组复发率均低于对照组,差异具有统计学意义(P<0.05);泡腾片组、栓剂组复发率相当,差异无统计学意义(P>0.05);软膏组复发率最低,与泡腾片组和栓剂组比较,差异具有统计学意义(P<0.05)。结论在临床治疗细菌性阴道病过程中,采用双唑泰外用制剂临床效果显著,可在临床广泛使用,其常用剂型中软膏剂有效率及复发率等各项指标均优于泡腾片和栓剂。
Objective To investigate the curative effect of different dosage forms of bisoprolol in the treatment of bacterial vaginosis and to compare the curative effects. Methods The data of patients with bacterial vaginosis (BV) admitted to gynecology department of Liaoning Provincial Maternal and Child Hospital from January 2013 to March 2016 were retrospectively analyzed. According to the different drugs, they were divided into two groups: Metronidazole suppository group, double azole Thai ointment group and metronidazole tablets oral control group, after a course of treatment to compare the clinical efficacy and recurrence rate of other indicators. Results The effective rates of effervescent tablets group, suppository group, cream group and control group were 85.5%, 80.0%, 94.0%, 67.5% (P <0.05). Effervescent tablets group and suppository group had the same effect with no significant difference (P> 0.05). The ointment group had the best curative effect, which was better than that of effervescent tablet group And suppository group, the difference was statistically significant (P <0.05); effervescent tablet group, suppository group, ointment group recurrence rate were lower than the control group, the difference was statistically significant (P <0.05); effervescent tablet group, suppository (P> 0.05). The recurrence rate of the ointment group was the lowest, with statistical significance (P <0.05) compared with the effervescent tablet group and the suppository group. Conclusion In clinical treatment of bacterial vaginosis, the use of bisoprolol topical clinical significant effect, can be widely used in clinical practice, its commonly used formulations of ointment efficiency and recurrence rate and other indicators are better than effervescent tablets and suppositories .