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本实验结果表明,家兔静注PGE_2(Iμg/min/kg)后,动脉收缩压、静脉舒张压、平动脉压均显著下降,左室+dp/dt max,-dp/dt max、心肌耗氧量亦显著下降;心率、左室射血时间、左室收缩成分缩短速率,左室等容舒张期压力下降的时间常数均无明显改变。结果提示:家兔静注PGE_2,可降低动脉血压,减少心脏负荷,降低心肌耗氧量,但对心脏舒缩功能无明显影响。急性心肌梗塞的家兔,静注同剂量的PGE_2,可使+dP/dt max、-dp/dt max显著高于对照组;ST段抬高值亦显著低于对照组,LVSP高于对照组但无统计学意义。本结果亦进一步表明PGE_2可改善心肌血供,降低室壁张力,减少心肌耗氧量,以维持心脏功能。提示PGE_2对心肌梗塞具有保护作用。
The experimental results show that after intravenous administration of PGE 2 (Iμg/min/kg) in rabbits, arterial systolic pressure, venous diastolic pressure, and arterial pressure decrease significantly, left ventricular +dp/dt max, -dp/dt max, myocardial depletion Oxygen levels also decreased significantly; heart rate, left ventricular ejection time, left ventricular contraction component shortening rate, left ventricular isovolumetric diastolic pressure time constants did not change significantly. The results suggest that intravenous injection of PGE 2 in rabbits can reduce arterial blood pressure, reduce cardiac load, and reduce myocardial oxygen consumption, but has no significant effect on cardiac diastolic function. In rabbits with acute myocardial infarction, intravenous infusion of PGE 2 at the same doses resulted in significantly higher +dP/dt max and -dp/dt max compared with the control group; ST elevation was also significantly lower than that of the control group, and LVSP was higher than that of the control group. However, it was not statistically significant. This result also shows that PGE 2 can improve myocardial blood supply, reduce the wall tension, and reduce myocardial oxygen consumption to maintain cardiac function. It is suggested that PGE_2 has a protective effect on myocardial infarction.