T2毒素对大鼠心电的影响

来源 :中国药理学与毒理学杂志 | 被引量 : 0次 | 上传用户:handan0918
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T2毒素是镰刀菌族中的一株单端孢霉烯族真菌毒素(trichotheccne mycotoxin),能引起人和动物复杂的全身系统综合征,如“食物中毒性白细胞减少症(ATA)”或“拟放射病”等。急性中毒因出血和心肺功能衰竭而死亡,慢性中毒引起心血管及免疫系统明显变化 。Yarom(1983)用离体和在体大鼠心脏标本,发现T2毒素可导致心脏及血管的严重损伤。本实验观察了T2毒素对清醒大鼠心电图的影响。 T2 toxin is a trichotheccne mycotoxin in the Fusarium family that causes complex systemic and systemic syndromes in humans and animals such as “food poisoning leukopenia (ATA)” or “ Radiation disease ”and so on. Acute poisoning died of hemorrhage and cardiopulmonary failure. Chronic poisoning caused significant changes in cardiovascular and immune systems. Yarom (1983) found that T2 toxin causes severe heart and blood vessel damage using isolated and in vivo rat heart specimens. The experiment observed T2 toxin on awake electrocardiogram.
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