神经周浸润(Perineural invasion,PNI),亦称为亲神经现象或嗜神经侵袭,1835年由Cruveilheir首先报道,其发现头颈部恶性肿瘤容易通过沿着神经生长而浸润进入颅内窝。后来的研究也表明在许多恶性肿瘤包括胰腺癌、结直肠癌、胆管癌、前列腺癌、膀胱癌等中均存在PNI,并显示其是一个重要的预后不良的病理因素。 Perineural invasion (PNI), also known as neuropsychiatric or neuropathic attacks, was first reported by Cruveilheir in 1835 and found that head and neck malignancies readily infiltrated into the intracranial fossa through nerve growth. Subsequent studies have also demonstrated the presence of PNI in many malignancies, including pancreatic cancer, colorectal cancer, cholangiocarcinoma, prostate cancer, bladder cancer, and the like, and have shown to be an important pathologic factor of poor prognosis.