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硫氮(艹卓)酮可以增加分级运动试验时从运动开始至出现心绞痛发作或明显ST段压低之间的运动时间.本文比较口服单剂硫氮(艹卓)酮120毫克和安慰剂3小时后,从运动开始到出现明显ST段压低(0.1毫伏)和高峰运动量之间的运动时间,固定次极量工作负荷时出现明显ST段压低和高峰运动量时的心肌氧需指数,以及高峰运动量时心电图缺血的程度.当硫氮(艹卓)酮导致上述变量明显改善时,测定其服药3小时后的药物血浆浓度和这些变化的关系.
Sulfanilamide increased exercise time from onset of exercise to episodes of angina pectoris or marked ST-segment depression during a fractional exercise test.This article compared 120 mg of a single dose of tiotropium and 3 hours of placebo After the onset of exercise, a significant ST-segment depression (0.1 mV) and peak exercise were recorded. The myocardial oxygen demand index was significantly decreased at ST sub-maximal workload and peak exercise When electrocardiogram ischemia resulted in a significant improvement in the above variables, the plasma concentrations of the drug after 3 hours and the changes were determined.