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目的 探讨左旋门冬酰胺酶 (L ASP)化疗的毒副作用及可行的防治方法。方法 回顾分析 139个疗程L ASP的使用 ,比较曾使用预防某种毒副作用措施的疗程及未使用预防该毒副作用措施的疗程的毒副作用发生率 ,分析防治措施的有效性。结果 139个疗程中 4 4个疗程产生如下毒副作用 :凝血障碍、过敏、急性胰腺炎、消化道反应、糖尿病、低蛋白血症、高脂血症。 5例患儿因L ASP毒副作用死亡。给予预防措施疗程和无预防措施疗程毒副作用发生率的差异有显著性意义。结论 积极预防可减少L ASP毒副作用 ,保证化疗顺利进行 ;及时诊断和处理L ASP毒副作用可减少严重合并症的发生 ,提高患儿的生存质量
Objective To investigate the toxic side effects of L-asparaginase (L ASP) chemotherapy and its possible prevention and treatment. Methods A retrospective analysis of 139 courses of L ASP use was used to prevent some toxic and side effects of the course of treatment and did not use the prevention and treatment of side effects of the toxic side effects of the treatment of the incidence of adverse reactions, analysis of the effectiveness of control measures. Results During the course of 139 courses, 4 4 courses had the following side effects: coagulopathy, allergy, acute pancreatitis, digestive tract reaction, diabetes, hypoproteinemia and hyperlipidemia. Five patients died of side effects of L ASP. There was a significant difference in the incidence of toxic and side effects of the courses of prophylaxis and nonpreventive courses of treatment. Conclusion The positive prevention can reduce the side effects of L ASP and ensure the smooth progress of chemotherapy. The prompt diagnosis and treatment of L ASP toxicity can reduce the incidence of serious complications and improve the quality of life in children