端粒、端粒酶与肿瘤发生的关系是近年来肿瘤研究领域的热点之一。端粒酶在 85 %以上的恶性肿瘤组织中阳性表达 ,在癌旁正常组织或良性肿瘤中仅为 4 2 % ,而在正常体细胞则一般为阴性。因此 ,有两种端粒酶相关的方式治疗端粒酶阳性的肿瘤细胞 ,一种是直接抑制端粒酶活性 ,另一种是靶向端粒酶表达的肿瘤细胞。把端粒酶作为肿瘤治疗的靶点为恶性肿瘤的早期诊断、预后估计及基因治疗开辟了一条新的途径 The relationship between telomere and telomerase and tumorigenesis is one of the hot spots in cancer research in recent years. Telomerase is positively expressed in more than 85% of malignant tumor tissues, only 42% of normal adjacent tissues or benign tumors, and negative in normal somatic cells. Therefore, there are two telomerase-related approaches for the treatment of telomerase-positive tumor cells, one that directly inhibits telomerase activity and one that targets telomerase-expressing tumor cells. Targeting telomerase as a tumor has opened up a new way for the early diagnosis, prognosis estimation and gene therapy of malignant tumors