1　病例报告患者男 ,5 7岁。因双膝关节游走性疼痛月余 ,晨僵 1ｈ来院诊治。实验室检查 :白细胞 10 5× 10 9/Ｌ ,血沉 2 5ｍｍ/ｈ ,类风湿因子阳性。诊断为类风湿性关节炎。给予芬必得胶囊 30 0ｍｇ ,早晚各服 1次 ,2天后疼痛缓解。第 3天出现双下肢水肿 ,体温 37 5℃ ,血压 1 case report patient male, 57 years old. Acromegaly due to the knee pain more than a month, morning stiffness 1h hospital for treatment. Laboratory tests: white blood cells 10 5 × 10 9 / L, erythrocyte sedimentation rate 2 5mm / h, rheumatoid factor positive. Diagnosis of rheumatoid arthritis. Give Fenbid capsules 30mg, morning and evening each serving 1, 2 days after the pain relief. Lower extremity edema appeared on the third day, body temperature 37 5 ℃, blood pressure