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目的探讨E钙黏蛋白(E-cadherin)和P63蛋白在宫颈癌组织中的表达及与临床病理特征的关系。方法选择2013年1月-2015年1月该院病理科收集的77例宫颈癌术后病理标本、通气收集的30例宫颈炎组织标本,采用免疫组化法检测两组标本中E-cadherin、P63蛋白的表达水平,探讨E-cadherin、P63蛋白表达与患者临床病理特征的关系。结果宫颈癌组织中的E-cadherin、P63蛋白阳性表达率分别为57.14%、49.35%均显著的低于宫颈炎组织的100.00%、100.00%,差异有统计学意义(P<0.05);宫颈癌组织中的E-cadherin、P63蛋白阳性表达率与患者的FIGO分期、组织分化程度、是否发生淋巴结转移具有显著的关系(P<0.05),与患者的年龄、病理类型关系不显著(P>0.05)。结论 E-cadherin、P63蛋白在宫颈癌组织中低表达,同时与宫颈癌的发生、发展及转移具有一定的关系。
Objective To investigate the expression of E-cadherin and P63 protein in cervical cancer and its relationship with clinicopathological features. Methods Seventy-one specimens of cervical cancer collected from January 2013 to January 2015 in our hospital were collected. The specimens of cervicitis collected by ventilation were collected. The expression of E-cadherin, P63 protein expression levels of E-cadherin, P63 protein expression and clinicopathological features. Results The positive rates of E-cadherin and P63 in cervical cancer tissues were 57.14% and 49.35%, respectively, which were significantly lower than 100.00% and 100.00% of those with cervicitis (P <0.05). Cervical cancer The positive expression rate of E-cadherin and P63 protein had significant relationship with FIGO staging, histological differentiation and lymph node metastasis (P <0.05), but not with age and pathological type (P> 0.05 ). Conclusions The expression of E-cadherin and P63 protein in cervical cancer is low, and has a certain relationship with the occurrence, development and metastasis of cervical cancer.