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为探讨肾功能减退是否与小管-间质病变(TIC)有关,作者观察伴肾病综合征(NS)的原发性膜性肾病(IMGN)55例,并与不伴NS的IMGN15例、伴NS的微小病变13例、弥漫性增殖性肾炎32例、膜增殖性肾炎6例作对照。小球病变程度(毛细血管破坏程度)以小球病变指数(IGL)表明,TIC程度以/S表明。T、S分别示肾皮质部小管面积与肾皮质部除去小球、血管之面积,取T的平均值与S之比(/S)可知小管萎缩程度。肾功能损害程度以Ccr表明。结果:伴及不伴NS的IMGN,其Ccr与/S明显正相关,与IGL不相关。对肾功能减退者
To investigate whether renal dysfunction is associated with tubulointerstitial lesions (TIC), we observed 55 patients with primary nephropathy (IMGN) with nephrotic syndrome (NS) and 15 with IMGN without NS, with NS 13 cases of micro-lesions, 32 cases of diffuse proliferative glomerulonephritis, 6 cases of membranous proliferative glomerulonephritis as control. Lesion degree of the pellet (degree of capillary destruction) The pelvic lesion index (IGL) shows that the degree of TIC is indicated by / S. T, S, respectively, showed renal cortical tubule area and renal cortical area to remove the ball, the vascular area, take the average value of T and S ratio (/ S) shows the extent of tubule atrophy. The extent of renal impairment is indicated by Ccr. Results: There was a significant positive correlation between Ccr and / S in IMGN with and without NS, which was not related to IGL. On renal dysfunction