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近年的研究表明,白细胞介素-2(IL-2)是免疫活性细胞相互作用的一种关键分子,是 T 淋巴细胞增殖所必需的。作者以往的研究证实了 PUVA 治疗能抑制某些 T 淋巴细胞的功能。为进一步了解 PUVA 改变 T 淋巴细胞功能的机制,作者研究了体内 PUVA 处理对小鼠脾细胞 IL-2产生的影响。
Recent studies have shown that interleukin-2 (IL-2) is a key molecule in the interaction of immunocompetent cells and is required for the proliferation of T lymphocytes. Previous studies by the authors confirm that PUVA treatment can inhibit the function of certain T lymphocytes. To further understand the mechanism by which PUVA alters T-lymphocyte function, we investigated the effect of PUVA treatment on IL-2 production in mouse splenocytes.