论文部分内容阅读
The enantiomers of a series of fourteen O-ethyl O-(substituted) phenyl N-isopropyl-phosphoroamidothioates have been separated by high performance liquid chromatography (HPLC) on the Pirkle-type chiral stationary phase. Seven molecular descriptors were calculated and four significant descriptors were chosen to correlate against the experimental Ink’ values in order to form the quantitative structure-enann’oselectivity retention relationships (QSERRs). Through the QSERRs, the retention and enantioselectivity mechanism were examined.
The enantiomers of a series of fourteen O-ethyl O- (substituted) phenyl N-isopropyl-phosphoroamidothioates have been separated by high performance liquid chromatography (HPLC) on the Pirkle-type chiral stationary phase. Seven molecular descriptors were calculated and four significant descriptors were chosen to correlate against the experimental Ink ’values in order to form the quantitative structure-enann’oselectivity retention relationships (QSERRs). Through the QSERRs, the retention and enantioselectivity mechanism were examined.