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目的:探讨体外受精-胚胎移植(IVF-ET)周期中不同年龄妇女的临床妊娠结局。方法:回顾性分析2002年1月至2006年12月在南方医院生殖医学中心进行IVF-ET治疗的1829个新鲜周期,比较不同年龄组之间的胚胎着床率、临床妊娠率、自然流产率。结果:本研究的平均临床妊娠率为46.7%。≤34岁组、35～37岁组、38～40岁组、41～42岁组、≥43岁组的胚胎着床率分别为33.3%、25.2%、13.3%、13.8%、5.0%,差异有显著性(P=0.000);临床妊娠率分别为50.5%、45.4%、25.8%、27.5%、11.1%,差异有显著性(P=0.000);自然流产率分别为5.3%、10.8%、11.8%、15.8%、0%,差异有显著性(P=0.004)。结论:患者年龄是影响IVF-ET妊娠结局的重要因素。随年龄增加,尤其是38岁以上的妇女,胚胎着床率与临床妊娠率明显降低,自然流产率显著升高。
Objective: To investigate the clinical pregnancy outcomes of women of different ages in IVF-ET cycles. Methods: The 1829 fresh cycles of IVF-ET treatment at Nanfang Hospital Reproductive Medicine Center from January 2002 to December 2006 were retrospectively analyzed. The embryo implantation rate, clinical pregnancy rate and spontaneous abortion rate among different age groups were compared . Results: The average clinical pregnancy rate in this study was 46.7%. The implantation rates of embryos ≤34 years old, 35 ~ 37 years old, 38 ~ 40 years old, 41 ~ 42 years old, ≥43 years old were 33.3%, 25.2%, 13.3%, 13.8% and 5.0% (P = 0.000). The clinical pregnancy rates were 50.5%, 45.4%, 25.8%, 27.5% and 11.1% respectively, with significant difference (P = 0.000) .The rates of spontaneous abortion were 5.3% and 10.8% 11.8%, 15.8%, 0%, the difference was significant (P = 0.004). Conclusion: Patient age is an important factor affecting the pregnancy outcome of IVF-ET. With age, especially in women over the age of 38, the embryo implantation rate and clinical pregnancy rate was significantly reduced spontaneous abortion rate was significantly increased.