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目的尿α1-MG作为早期肾损害标志物,对其进行筛查可早期发现慢性肾脏病,通过对肾功能在CKD G3期以上尿α1-MG进行分析,为早期筛查CKD提供理论依据。方法对982例健康体检尿常规蛋白为阴性的人群,对其尿α1-MG进行统计学分析。结果尿α1-MG的阳性率为25.3%,阳性与高血压、糖尿病、冠心病、糖化血红蛋白水平、空腹血糖水平、高甘油三脂、低高密度脂蛋白胆固醇、吸烟、饮酒有关,其中高血压、空腹血糖、吸烟是其独立危险因素。结论在尿蛋白为阴性的情况下,对高危人群需行尿α1-MG检查是十分必要的。
Purpose Urinary α1-MG as a marker of early renal damage, its screening for early detection of chronic kidney disease, urinary α1-MG over the kidney CKD G3 in the analysis for the early screening of CKD provides a theoretical basis. Methods A total of 982 subjects with negative urinalysis in healthy subjects were tested for urinary α1-MG. Results The positive rate of urine α1-MG was 25.3%. The positive rate was related to hypertension, diabetes, coronary heart disease, glycosylated hemoglobin, fasting blood glucose, high triglyceride, low-density lipoprotein cholesterol, smoking and drinking, , Fasting blood glucose, smoking is an independent risk factor. Conclusion In the case of negative urinary protein, urinary α1-MG examination is very necessary for high-risk groups.