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目的观察咖啡酸片联合地榆升白片促进急性白血病化疗后造血恢复的疗效和不良反应。方法观察组在化疗开始同时口服咖啡酸片,每次300 mg,3次/d,地榆升白片每次400 mg,3次/d,对照组在化疗结束后白细胞<4×109/L时皮下注射重组人粒细胞集落刺激因子(G-CSF)每天300 ug,两组均于白细胞>4×109/L和PLT>100×109/L停药。比较第7天、第14天、第21天白细胞、血红蛋白血、血小板水平,以及总体感染率及人均血小板输注量。结果两组第7天、第14天、第21天白细胞、血红蛋白血及总体感染率无显著性差异(P>0.05);第14天第21天观察组血小板水平显著高于对照组(P<0.05),观察组人均血小板输注量显著少于对照组(P<0.05)。结论咖啡酸片联合地榆升白片促进急性白血病化疗后造血恢复疗效显著,不良反应轻。
Objective To observe the curative effect and side effects of caffeic acid tablets combined with Yuyu Shengbai tablet in promoting hematopoietic recovery after chemotherapy of acute leukemia. Methods At the beginning of chemotherapy, the observation group received oral administration of caffeic acid tablets at a dose of 300 mg / d for 3 times a day. Allium dulcis rose white tablets were treated with 400 mg / d for 3 times a day. In the control group, white blood cells were less than 4 × 109 / L after chemotherapy When the G-CSF was subcutaneously administered 300 μg daily, both groups were discontinued with leukocyte> 4 × 109 / L and PLT> 100 × 109 / L. The levels of white blood cells, hemoglobin, platelets on day 7, day 14, and day 21 were compared with the overall infection rate and per capita platelet transfusion volume. Results There was no significant difference in the leukocyte, hemoglobin and total infection rate between the two groups on the 7th, 14th and 21st days (P> 0.05). On the 14th day, the platelet level in the observation group was significantly higher than that in the control group (P < 0.05). The mean perfused platelet volume in the observation group was significantly less than that in the control group (P <0.05). Conclusion The combination of caffeic acid tablets and Yuyu Shengbai Tablet can promote the hematopoietic recovery after acute leukemia chemotherapy, and the adverse reactions are mild.