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目的分析毛细胞黏液样星形细胞瘤(PMA)患者的临床资料,探讨治疗模式与预后的关系。方法回顾性分析11例术后病理确诊为PMA的患者临床资料,其中6例术后行放化疗,分析患者生存状况,比较单纯手术组与放化疗组生存期(OS)。结果随访至2016年8月,两组患者中位随访时间为21(2~55)个月,中位OS为24个月,1年生存率为90.9%。两组OS比较差异无统计学意义(P=0.23),但对比术后3个月两组生活质量状况(KPS),放化疗组KPS明显优于单纯手术组(P=0.047)。结论 PMA发病率低、预后不良,手术切除是最主要治疗手段,放化疗的价值有待进一步研究。
Objective To analyze the clinical data of patients with hairy myxoid astrocytoma (PMA) and to explore the relationship between the treatment mode and the prognosis. Methods The clinical data of 11 patients with postoperative pathological diagnosis of PMA were retrospectively analyzed. Among them, 6 patients were treated with chemoradiotherapy after operation. Survival status was analyzed. Survival (OS) was compared between the operation and radiotherapy and chemotherapy groups. The results were followed up until August 2016. The median follow-up time was 21 months (range 2 to 55). The median OS was 24 months and the 1-year survival rate was 90.9%. There was no significant difference in the OS between the two groups (P = 0.23). However, the KPS of the two groups after 3 months of operation was significantly better than that of the simple operation group (P = 0.047). Conclusion The incidence of PMA is low and the prognosis is poor. Surgical resection is the most important treatment. The value of chemoradiotherapy remains to be further studied.