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本实验比较观察益气活血及疏肝理气两类治则方药对家兔实验性高脂血症及动脉粥样硬化的影响,并从胆汁脂质成份、血浆LPO浓度、环核苷酸及TXA_2-PGI_2水平、血液流变学等指标探讨其机理。结果发现:(1)两类治则方药均有降血胆固醇、改善动脉粥样斑块的作用,且前方优于后方;(2)两类治则方药均能改变胆汁中脂质含量,减少胆石生成,但后方优于前方;(3)改善动脉粥样硬化的机理与降低血脂、降低LPO、提高cAMP/cGMP及改善TXB_2/6-KPGF_(1α)比值有关。实验提示不同方剂可因作用于相同发病环节而起到同病异治的作用。
This experiment compared the effect of Yiqihuoxue and Shuganliqi on the experimental hyperlipidemia and atherosclerosis in rabbits, and from the bile lipid composition, plasma LPO concentration, cyclic nucleotides and TXA_2 -PGI 2 level, hemorheology and other indicators to explore its mechanism. The results showed that: (1) Both types of treatment prescriptions have the effect of lowering blood cholesterol and atherosclerotic plaque, and the front is better than the rear; (2) Both types of Zhifang Recipe can change the lipid content in the bile and reduce Gallstones were generated, but the posterior aspect was superior to the anterior aspect. (3) The mechanism of improving atherosclerosis was related to lowering blood lipids, lowering LPO, increasing cAMP/cGMP, and improving TXB_2/6-KPGF_(1α) ratio. Experiments suggest that different prescriptions can play the same role in the same disease due to the same disease path.