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磺脲类和新一类“格列奈”口服降糖药能通过关闭胰岛β细胞上的 ATP 敏感性 K 通道而刺激胰岛素分泌,但它们对心脏、血管平滑肌和骨骼肌等胰外组织也有影响。胰岛β细胞的 ATP 敏感性 K 通道的药理学特性与心脏、血管平滑肌和骨骼肌等处的不同,它们通过不同类型的磺脲药受体和不同的药物结合位点起作用。考虑到 ATP 敏感性 K 通道关闭可能对人类有副作用,应强调这些药物的不同作用,并用 ATP 敏感性 K 通道关闭对胰外组织影响较轻或无作用的药物。更需进一步研究在2型糖尿病治疗中应用非选择性磺脲药是否恰当。
Sulphonylureas and a new class of “grenadine” oral hypoglycemic agents stimulate insulin secretion by switching off the ATP-sensitive K channels on islet beta cells, but they inhibit the synthesis of extrahepatic tissues such as heart, vascular smooth muscle and skeletal muscle Also influential. ATP Sensitivity of Pancreatic β Cells The pharmacological properties of K channels, unlike those at the heart, vascular smooth muscle and skeletal muscle, etc., act through different types of sulfonylurea receptors and different drug binding sites. Taking into account the ATP-sensitive K-channel closure may have side effects on humans, the different effects of these drugs should be emphasized and drugs with less or no effect on the extrapancreatic tissue should be switched off with the ATP-sensitive K channel. Further study is needed in the treatment of type 2 diabetes with non-selective sulfonylurea appropriate.